Julia Belk Eric Topol Nathan Zemke
Event Information
Event Topic:
Updated BIONews and a video- Two Landmark Studies Challenge Dogma About our Brain Immune Cells and Aging
Event Description:
Landmark human brain-aging studies challenge the idea of steady, inevitable deterioration. Around age 50, major molecular changes emerge in the hippocampus, including astrocyte energy dysfunction, inflammation, and weakening of the blood-brain barrier. Blood-derived monocytes then increasingly enter the brain and transform into inflammatory “Micro2” cells, replacing resident microglia—a process more pronounced in men and extending beyond the hippocampus. Intriguingly, some blood-cell mutations associated with CHIP may instead enhance amyloid clearance and reduce Alzheimer’s pathology. Together, multiomics and genome-tracking studies reveal a dynamic brain–immune axis, suggesting new strategies to prevent neuroinflammation, Alzheimer’s disease, and cognitive decline.
Date/Time:
Date(s) - 09/08/26
6:15 pm - 8:15 pm
Event Location:
Zoom talk: https://us02web.zoom.us/j/83593256859:
Speaker Information
Event Speaker:
Julia Belk and Nathan Zemke w/ Eric Topol
Event Speaker Title:
JB-Stanford Postdoctoral Scholar, Pathology; NZ - principal investigator at the UC San Diego Center for Epigenomics
Event Speaker Company:
Event Speaker Bio:
Event Details
Cost:
$0
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