Computational Biology Applied to Liver Cells in vitro - High Throughput Screen for Drug Toxicity-Dr. Mike Bowles-01/15/2013 - 8:30am

Event Information
Event Topic: 
Computational Biology Applied to Liver Cells in vitro - High Throughput Screen for Drug Toxicity
Event Date: 
01/15/2013 - 8:30am
Event Location: 
Sunnyvale City Council Chambers, 456 West Olive Ave., Sunnyale, CA
Speaker Information
Event Speaker: 
Dr. Mike Bowles
Event Speaker Title: 
Event Speaker Company: 
Event Speaker Bio: 

Dr. Mike Bowles

Dr. Mike Bowles' career is one of the most extraordinary in Silicon Valley. Mike’s career started out in research, as an assistant professor at MIT. He went on to found and run two companies, both of which went on to huge IPOs: First was Com21, an early pioneer in developing cable modem networks, which Mike led to a successful NASDAQ IPO at a $300m valuation. He then went on to create IBeam Broadcasting, a video distribution network, which after just 2.5 years he led to a $3b IPO. More recently he has been active as co-founder of biotech firm Biomatica which grew out of data mining courses Mike runs at Hacker Dojo.

Event Details
Event Details: 

We all know drug development is too expensive and slow with testing for long term side effects is a major factor. Liver damage is one of the worst potential side effects of drugs, taken alone or with other medicines. The basic idea is to replace liver toxicology studies on live rats with machine learned models of liver damage that can be run on rat (or human) liver cells grown in culture. We're seeing very good prediction accuracy. The work was the topic of a paper that my co-founder and I presented this summer at CAMDA - (part of ISMB - organized by International Society for Computational Biology).