Cell-Bonding Peptides and Biomimetic Implants-Cheng Li, Ph.D.-04/24/2012 - 8:30am

Event Information
Event Topic: 
Cell-Bonding Peptides and Biomimetic Implants
Event Date: 
04/24/2012 - 8:30am
Event Location: 
Sunnyvale City Council Chambers, 456 West Olive Ave., Sunnyale, CA
Speaker Information
Event Speaker: 
Cheng Li, Ph.D.
Event Speaker Title: 
Event Speaker Company: 
Event Speaker Bio: 

Cheng Li, Ph.D. - Consultant for Program Management and Product Development

Dr. Cheng Li has broad experience in developing medical devices and drug delivery systems. Some examples include drug-eluting stents, vascular grafts, inhalation devices for morphine and insulin, bioadhesives, and intraocular lenses. Cheng has managed many new product development programs from concept to commercialization. His professional experience ranges from startups to Fortune 500 companies. Prior to becoming a technology and business development consultant, he was responsible for developing dual drug-eluting stents at Cordis, a Johnson & Johnson company.

Cheng is a graduate of University of Southern California with a Ph.D. Degree in Polymer Chemistry and Engineering. He also earned a MBA Degree in Program Management from Saint Mary’s College of California. Cheng has over 40 patents and publications.

Event Details
Event Details: 

Cell-Bonding Peptides and Biomimetic Implants

Most medical implant materials used today are biocompatible, or more precisely bioinert. They are nontoxic and stable against degradation in the tissue. However, these materials cannot be fully integrated into surrounding tissues because foreign body reaction, inflammatory response, and thrombosis not only prevent strong biological interactions between implant materials and surrounding tissues, but also accelerate fibrous encapsulation. This poor tissue integration is mainly due to insufficient cellular recognition and weak healing responses.

In the past twenty years, the biomaterials research has been very actively searching for biomimetic materials that are able to replace lost organ functions and create functional tissue structures. Biomimetic materials need to have required mechanical properties for intended functions and, more importantly, they must be able to recognize, support, promote, and interact with surrounding cells. Currently, there are two major approaches to develop new biomimetic materials: (1) Generate a tissue-like matrix by combining cells and growth factors with biomaterial scaffolds; (2) Create a biomimetic surface by attaching cell-binding peptides or extracellular matrixes (ECMs) onto the surface of biomaterials.

Cell-binding peptide or ECM molecules can lead to strong biological interactions between surrounding cells and the implant surface because they have specific cell adhesion domains. It is much easier to covalently immobilize cell-bonding peptides onto the surface of biomaterials compared to large ECM molecules, such as fibronectin, vitronectin, or collagen.
This approach can significantly improve cell adhesion, wound healing, and tissue integration without altering intended mechanical properties for implant materials.

This seminar will discuss how to use liner and branched cell-binding peptides to enable biomaterials to elicit specific cellular responses and direct new tissue integration mediated by biomolecular recognition. An application for biomimetic vascular grafts developed by the author will be presented as an example.